SLUG (SNAI2) Mouse Monoclonal Antibody [Clone ID: OTI4B3]

Specifications

Product Data
Clone Name	OTI4B3
Applications	WB
Recommend Dilution	WB 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human SNAI2 (NP_003059) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29.8 kDa
Gene Name	snail family transcriptional repressor 2
Database Link	NP_003059 Entrez Gene 20583 MouseEntrez Gene 25554 RatEntrez Gene 6591 Human UniProt ID O43623
Background	This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq]
Synonyms	SLUG; SLUGH1; SNAIL2; WS2D
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Adherens junction

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