Munc 13 4 (UNC13D) Mouse Monoclonal Antibody [Clone ID: OTI1F4]

Specifications

Product Data
Clone Name	OTI1F4
Applications	WB
Recommend Dilution	WB 1:200~1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human UNC13D(NP_954712) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	123.1 kDa
Gene Name	unc-13 homolog D
Database Link	NP_954712 Entrez Gene 70450 MouseEntrez Gene 192177 RatEntrez Gene 201294 Human UniProt ID Q70J99
Background	This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Synonyms	FHL3; HLH3; HPLH3; Munc13-4
Reference Data

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