PMS2 Mouse Monoclonal Antibody [Clone ID: OTI4B7]

Specifications

Product Data
Clone Name	OTI4B7
Applications	IF, IHC, WB
Recommend Dilution	WB 1:500, IHC 1:150, IF: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PMS2(NP_000526) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	95.6 kDa
Gene Name	PMS1 homolog 2, mismatch repair system component
Database Link	NP_000526 Entrez Gene 5395 Human UniProt ID P54278
Background	This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008]
Synonyms	HNPCC4; PMS2CL; PMSL2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Mismatch repair

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