ACTH (POMC) Mouse Monoclonal Antibody [Clone ID: OTI1A8]

CAT#: CF506608

Carrier-free (BSA/glycerol-free) POMC mouse monoclonal antibody, clone OTI1A8 (formerly 1A8)

Formulation: Standard Carrier-Free



  View other "OTI1A8" antibodies (4)

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CNY 3,999.00


货期*
2周

规格
    • 100 ug

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Biotinylation Labelling Kit formatted 4 x 0.05mg
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Specifications

Product Data
Clone Name OTI1A8
Applications IF, IHC, WB
Recommend Dilution WB 1:4000, IF 1:100
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human POMC(NP_001030333) produced in HEK293T cell.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 26.6 kDa
Gene Name proopiomelanocortin
Background This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Synonyms ACTH; CLIP; LPH; MSH; NPP; POC
Reference Data
Protein Families Druggable Genome
Protein Pathways Adipocytokine signaling pathway, Melanogenesis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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