p73 (TP73) Mouse Monoclonal Antibody [Clone ID: OTI2H5]

Specifications

Product Data
Clone Name	OTI2H5
Applications	IF, IHC, WB
Recommend Dilution	WB 1:4000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 167-409 of human TP73 (NP_005418) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69.4 kDa
Gene Name	tumor protein p73
Database Link	NP_005418 Entrez Gene 362675 RatEntrez Gene 7161 Human UniProt ID O15350
Background	This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb
Synonyms	P73
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Neurotrophin signaling pathway, p53 signaling pathway

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