NLN Mouse Monoclonal Antibody [Clone ID: OTI3A12]

Specifications

Product Data
Clone Name	OTI3A12
Applications	FC, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human NLN(NP_065777) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	80.5 kDa
Gene Name	neurolysin
Database Link	NP_065777 Entrez Gene 75805 MouseEntrez Gene 117041 RatEntrez Gene 57486 Human UniProt ID Q9BYT8
Background	This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
Synonyms	AGTBP; EP24.16; MEP; MOP
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Renin-angiotensin system

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