PPM1B Mouse Monoclonal Antibody [Clone ID: OTI3E8]

Specifications

Product Data
Clone Name	OTI3E8
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PPM1B(NP_002697) produced in HEK293 cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52.5 kDa
Gene Name	protein phosphatase, Mg2+/Mn2+ dependent 1B
Database Link	NP_002697 Entrez Gene 19043 MouseEntrez Gene 24667 RatEntrez Gene 5495 Human UniProt ID O75688
Background	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq]
Synonyms	PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
Reference Data
Protein Families	Druggable Genome, Phosphatase, Stem cell - Pluripotency
Protein Pathways	MAPK signaling pathway

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