PNMT Mouse Monoclonal Antibody [Clone ID: OTI2F2]

Specifications

Product Data
Clone Name	OTI2F2
Applications	IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PNMT (NP_002677) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30.7 kDa
Gene Name	phenylethanolamine N-methyltransferase
Database Link	NP_002677 Entrez Gene 18948 MouseEntrez Gene 5409 Human UniProt ID P11086
Background	The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. [provided by RefSeq]
Synonyms	PENT; PNMTase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tyrosine metabolism

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