Gephyrin (GPHN) Mouse Monoclonal Antibody [Clone ID: OTI2C2]

Specifications

Product Data
Clone Name	OTI2C2
Applications	FC, IF, WB
Recommend Dilution	WB 1:500~2000, IF 1:100, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human GPHN (NP_065857) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	83.3 kDa
Gene Name	gephyrin
Database Link	NP_065857 Entrez Gene 64845 RatEntrez Gene 268566 MouseEntrez Gene 10243 Human UniProt ID Q9NQX3
Background	This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq]
Synonyms	GEPH; GPH; GPHRYN; HKPX1; MOCODC
Reference Data
Protein Families	Druggable Genome

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