Ribonuclease Inhibitor (RNH1) Mouse Monoclonal Antibody [Clone ID: OTI3F11]

Specifications

Product Data
Clone Name	OTI3F11
Applications	FC, IHC, WB
Recommend Dilution	WB 1:500~2000, FLOW 1:100, IHC: 1:150
Reactivity	Human, Dog, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human RNH1 (NP_002930) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49.8 kDa
Gene Name	ribonuclease/angiogenin inhibitor 1
Database Link	NP_002930 Entrez Gene 100360501 RatEntrez Gene 483402 DogEntrez Gene 720791 MonkeyEntrez Gene 6050 Human UniProt ID P13489
Background	Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo. [supplied by OMIM]
Synonyms	RAI; RNH
Reference Data

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