Hsp22 (HSPB8) Mouse Monoclonal Antibody [Clone ID: OTI1E3]

Specifications

Product Data
Clone Name	OTI1E3
Applications	FC, IF, WB
Recommend Dilution	WB 1:500~2000, IF 1:100, FLOW 1:100
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human HSPB8(NP_055180) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	21.4 kDa
Gene Name	heat shock protein family B (small) member 8
Database Link	NP_055180 Entrez Gene 80888 MouseEntrez Gene 113906 RatEntrez Gene 26353 Human UniProt ID Q9UJY1
Background	The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq]
Synonyms	CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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