Cytochrome P450 Reductase (POR) Mouse Monoclonal Antibody [Clone ID: OTI3H10]

Specifications

Product Data
Clone Name	OTI3H10
Applications	FC, IF, IHC, WB
Recommend Dilution	WB 1:1000, IHC 1:50, IF 1:100, Flow 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human POR expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	76.7 kDa
Gene Name	cytochrome p450 oxidoreductase
Database Link	NP_000932 Entrez Gene 18984 MouseEntrez Gene 29441 RatEntrez Gene 5447 Human UniProt ID P16435
Background	This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
Synonyms	CPR; CYPOR; P450R
Reference Data
Protein Families	Druggable Genome, P450, Transmembrane

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