VMAT2 (SLC18A2) Mouse Monoclonal Antibody [Clone ID: OTI10C11]

Specifications

Product Data
Clone Name	OTI10C11
Applications	IHC, WB
Recommend Dilution	WB 1:500 IHC 1:50
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human SLC18A2 expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.7 kDa
Gene Name	solute carrier family 18 member A2
Database Link	NP_003045 Entrez Gene 25549 RatEntrez Gene 214084 MouseEntrez Gene 6571 Human UniProt ID Q05940
Background	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles,using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine
Synonyms	SVAT; SVMT; VAT2; VMAT2
Reference Data
Protein Families	Transmembrane
Protein Pathways	Parkinson's disease

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