TrkB (NTRK2) Mouse Monoclonal Antibody [Clone ID: OTI2E1]

Specifications

Product Data
Clone Name	OTI2E1
Applications	IF, IHC, WB
Recommend Dilution	WB 1:1000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human NTRK2 (NP_001007098) produced in HEK293T cell
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	92 kDa
Gene Name	neurotrophic receptor tyrosine kinase 2
Database Link	NP_001007098 Entrez Gene 18212 MouseEntrez Gene 25054 RatEntrez Gene 4915 Human UniProt ID Q16620
Background	This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene
Synonyms	GP145-TrkB; trk-B; TRKB
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	MAPK signaling pathway, Neurotrophin signaling pathway

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