BMP10 (86-96) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	Peptide-ELISA: 1/50 - 1/200. In a simple ELISA using 1 µg of antigen coated per well, the 50% OD was observed at an antibody dilution of 1/100. With 1 µg of peptide-BSA coated per well the 50% OD was observed at 1/2500. Under the same conditions the end point was observed at 1/80K. Competitive ELISA: pep-BSA plates, coated at 1 µg/well, antibody diluted 1/10K. Pep-BSA displaces in the range 0.1 to 100 µg/ml. The free peptide does not displace in this assay system.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugate; sequence: C-L-D-K-G-V-V-T-Y-K-F-K
Specificity	Bone Morphogenetic Protein 10 (BMP-10) 86-96.
Formulation	PBS, pH 7.2, with 0.09% sodium azide as preservative. State: Purified State: Liquid, purified immunoglobulin fraction
Concentration	lot specific
Purification	Ammonium sulphate fractionation
Conjugation	Unconjugated
Storage Condition	Shipping 2-8°C. Upon receipt aliquot and store at -20°C. Avoid repeated freezing and thawing.
Gene Name	bone morphogenetic protein 10
Database Link	Entrez Gene 27302 Human UniProt ID O95393
Background	Bone morphogenetic protein-10 (BMP10) belongs to the transforming growth factor beta (TGFß) family. BMPs, named for their initial biological activity of inducing ectopic bone formation, have been linked to multiple steps of cardiac development. BMP10 is translated as a precursor protein (preproprotein) with N-terminal hydrophobic leader peptide followed by prodomain and the mature C-terminal region that is released after the cleavage at multibasic motif RXRR. Data strongly suggest that BMP10 is an essential component in modulating cardiomyocyte proliferation and maturation during cardiac ventricular development.
Synonyms	Bone morphogenetic protein 10, BMP-10
Reference Data

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