KRT13 Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/3000 (ECL method). Immunohistochemistry on Frozen Sections: 1/200. Immunohistochemistry on Paraffin Sections: 1/100 (after microwave treatment). Immunohistochemistry on Cytological Material. Positive Control: Squamous epithelium of esophagus, gingival, palate, vagina (staining all of the suprabasal layers). Incubation Time: 1h at RT, extended with Paraffin Sections.
Reactivity	Human, Mouse
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic peptide (TTTSSASVTTTSNA-C) of Human keratin K13 (formerly also designated cytokeratin 13), coupled to KLH.
Specificity	This antibody recognizes Acidic Human keratin K13 (Mr 55 000). Excellent marker to discriminate non-cornified squamous epithelia (esophagus, vagina, gingival) from those of different origin. Negative on foot sole, scalp. Tumors Specifically Detected: Several squamous cell carcinomas, e.g. cervix carcinoma; transitional cell carcinoma of the bladder; craniopharyngioma.
Formulation	State: Serum State: Stabilized Liquid antiserum Stabilizer: 0.5% BSA Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	keratin 13
Database Link	Entrez Gene 3860 Human UniProt ID P13646
Background	Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.
Synonyms	CK-13, CK13, Keratin-13, KRT13, K13, KRT-13
Reference Data

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