Gastrin (GAST) Guinea Pig Polyclonal Antibody
CAT#: BP5046
Gastrin (GAST) guinea pig polyclonal antibody, Serum
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CNY 5,291.00
货期*
5周
规格
Cited in 6 publications. |
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Specifications
Product Data | |
Applications | IF, IHC |
Recommend Dilution | Immunohistochemistry on Frozen Sections: 1:1,000-1:1,500 Immunohistochemistry on Paraffin Embedded Tissues: 1:1,000-1:1,500 (microwave treatment recommended) Immunofluorescence Microscopy. Recommended Positive Control: Formalin-fixed paraffin sections of Rat antrum. Working Dilutions: 1:1,000-1:1,500 using FITC, with overnight incubation at 2-8°C. |
Reactivity | Human, Rat |
Host | Guinea Pig |
Clonality | Polyclonal |
Immunogen | Synthetic Human Gastrin I conjugated to BSA |
Specificity | Gastrin-secreting cells are numerous in the antrum and a few are found in the proximal duodenum. The antibody can be used for the diagnosis of Gastrin-producing tumors which are mainly found in the pancreas and occasionally in the stomach and the duodenum. Absorption with 10-100 µg Gastrin 1-34 and CCK 8 per ml antiserum abolishes the staining. |
Formulation | State: Serum State: Lyophilized Serum |
Reconstitution Method | Restore in 100 µl distilled water |
Conjugation | Unconjugated |
Storage Condition | Prior to reconstitution store at 2-8°C. |
Gene Name | gastrin |
Database Link | |
Background | Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. |
Synonyms | GAST, GAS |
Reference Data |
Citations (6)
The use of this Antibodies has been cited in the following citations: |
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Mechanosensitive ion channel Piezo1 is expressed in antral G cells of murine stomach
,Lang K, Breer H, Frick C,
Cell Tissue Res.
,PubMed ID 29264643
[GAST]
|
High fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach
,Widmayer P, Goldschmid H, Henkel H, K|per M, Kvnigsrainer A, Breer H,
Front Physiol
,PubMed ID 25774135
[GAST]
|
Complex morphology of gastrin-releasing G-cells in the antral region of the mouse stomach.
,null,
Cell and tissue research
,PubMed ID 27392412
[GAST]
|
Receptors responsive to protein breakdown products in g-cells and d-cells of mouse, swine and human
,Haid DC, Jordan-Biegger C, Widmayer P, Breer H,
Front Physiol
,PubMed ID 22514536
[GAST]
|
Nutrient sensing receptors in gastric endocrine cells
,Haid D, Widmayer P, Breer H,
J. Mol. Histol.
,PubMed ID 21750971
[GAST]
|
Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1
,Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S,
J. Clin. Endocrinol. Metab.
,PubMed ID 18697876
[GAST]
|
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