Perilipin 3 (PLIN3) (C-term) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/1000 (ECL).  Immunohistochemisty on Frozen Sections: 1/100-1/200.  Immunohistochemisty on Paraffin Sections: 1/100-1/200 after microwave treatment (See Straub et al. 2008 for protocol).  Incubation Time: 1 h at RT for immunohistochemistry.
Reactivity	Human
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic peptide of TIP47 C-terminus (hCTA/B; aa 420 - 431); C-terminal epitope.
Specificity	This antibody recognizes TIP47 / PP17 / PLIN3 (C-terminus).  This antiserum, however, is specific for TIP47 (PLIN3) and does not cross-react with Adipophilin (PLIN2) and Perilipin (PLIN1) or other closely related members of the PLIN/PAT-family. Tested Reactivity on Cultured Cell Lines: PLC.
Formulation	State: Serum State: Liquid Serum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	perilipin 3
Database Link	Entrez Gene 10226 Human UniProt ID O60664
Background	TIP47 (tail-interacting protein of 47 kD; also named PLIN3) is involved in lipid droplet maturation (see e.g. Bulankina 2003 and 2009). The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. After radical surgery TIP47 serum levels are decreased (cf. Than et al.). TIP47 shows about 40% sequence homology to adipophilin (PLIN2).
Synonyms	M6PRBP1; PP17; TIP47
Reference Data
Protein Families	Druggable Genome

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