Complement C4A (C4A) (neoepitope) Chicken Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: The titer with native Human C4a was > 1/1000.
Reactivity	Human
Host	Chicken
Clonality	Polyclonal
Immunogen	Synthetic peptide coupled to carreir protein.
Specificity	This antibody was found not to cross-react with Human C3a. The antibody was generated against the carboxy-terminal neoepitope which is not exposed on C4, allowing discrimination between C4 and C4a.
Formulation	PBS, pH 7.2 State: Aff - Purified State: Liquid purified IgY fraction Stabilizer: 30% Glycerol Preservative: 0.09% Sodium Azide
Concentration	0.5 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month. Avoid repeated freezing and thawing.
Gene Name	complement component 4A (Rodgers blood group)
Database Link	Entrez Gene 720 Human UniProt ID P0C0L4
Background	The complement system is part of the innate immune system representing humoral defence. Activation of the complement cascade via the the alternative pathway liberates several biologically active by-products, among them the anaphylatoxin C4a. Measurement of C4a (and C3a) in plasma or other body fluids can yield important clues about the pathological, and particularly also the inflammatory status of an organism. In serum, C4a activity is under control of the carboxypeptidase N. This enzyme rapidly cuts off the C-terminal arginine, thereby generating C4adesArg. This degradation product C4adesArg remains relatively stable until it is cleared from the circulation.
Synonyms	Complement component 4, CPAMD2, CPAMD3, Acidic complement C4, Basic complement C4
Reference Data
Protein Pathways	Complement and coagulation cascades, Systemic lupus erythematosus

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