Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (aa 493-502) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	Has been characterized by Western blotting, ELISA, and cell staining techniques. Suitable for immunocytochemical (ABC techniques, 1/400 dilution) and western immunoblotting (tissue homogenates, 1/800 dilution, single band at 63 kDa) detection of the receptor.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide analogue of the carboxyl terminal (aa 493-502) of the human nicotinic alpha 7 receptor attached to a carrier protein.
Specificity	Specific for the COOH terminal of nicotinic alpha 7 receptor. Cross-reactivity: Nicotinic alpha 7 receptor (493-502): 100% Nicotinic alpha 7 receptor: ~85% No Cross-reactivity with Nicotinic alpha 3 receptor, Nicotinic alpha 4 receptor, Nicotinic alpha 5 receptor, Nicotinic beta 2 receptor, Nicotinic beta 3 receptor and Nicotinic beta 4 receptor.
Formulation	State: Serum State: Lyophilized neat serum Preservative: None
Reconstitution Method	Restore with 0.1 ml PBS containing 10 mg/ml BSA or with additional buffer for more dilute antisera.
Conjugation	Unconjugated
Storage Condition	Lyophilized: Store at 2-8°C (preferably in a dessicator). Reconstituted: Aliquot and store at -20°C. Avoid repeated freezing and thawing.
Gene Name	cholinergic receptor nicotinic alpha 7 subunit
Database Link	Entrez Gene 1139 Human UniProt ID P36544
Background	Nicotinic acetylcholine receptors (nAChRs), are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. Following acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Synonyms	Nicotinic acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7
Reference Data

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