Dopamine D2 Receptor (DRD2) (long isoform, 243-254) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	Immunocytochemical detection of the D2L dopamine receptor : this antiserum has been found to be stain specific cells in various regions of PLP fixed rat brain sections. This includes Medial septum, Nucleus accumbens, Dentate gyrus, Globus pallidus, Medial forebrain bundle, Cortex regions 1-3, Substantia Nigra reticulata, and the Ventral tegmental area. Western immunoblots using whole rat brain homogenate resulted in a single band being detected at ~51 kD at 1:400 dilution.
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	D2L (243-254) cyclized covalently attached to a carrier protein.
Specificity	Specific for D2L Dopamine Receptor (a.a. 243-254)cyclized. This antisera has been characterized by immunocytochemical, Western immunoblot and ELISA techniques. Cross-reactivity: D2L Dopamine Receptor (243-254)cyclized 100% D2 Dopamine Receptor ~50% D1 Dopamine Receptor (9-21) 0% D1 Dopamine Receptor 0% D3 Dopamine Receptor (2-10) 0% D3 Dopamine Receptor 0% D4 Dopamine Receptor (176-185) 0% D4 Dopamine Receptor 0% D5 Dopamine Receptor (23-35) 0% D5 Dopamine Receptor 0%
Formulation	State: Serum State: Lyophilized neat serum without stabilizers and preservatives.
Reconstitution Method	Reconstitute with 0.1 ml of PBS which contains 10 mg/ml BSA or with additional buffer for more dilute antisera.
Conjugation	Unconjugated
Storage Condition	Lyophilized: Store at 2-8°C (preferably in a dessicator). Reconstituted: Aliquot and store at -20°C. Avoid repeated freezing and thawing.
Gene Name	dopamine receptor D2
Database Link	Entrez Gene 1813 Human UniProt ID P14416
Background	The dopamine D2 receptor belongs to the G-protein coupled receptor 1 family and inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms, a short and a long isoform.
Synonyms	DRD2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Gap junction, Neuroactive ligand-receptor interaction

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