Rotavirus (NCDV) Goat Polyclonal Antibody

CAT#: BP1055P

Rotavirus (NCDV) goat polyclonal antibody, Purified



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CNY 11,100.00


货期*
5周

规格
    • 1 ml

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Specifications

Product Data
Applications IF
Recommend Dilution Immunofluorescence (1/250).
Also suitable for conjugation purposes.
Reactivity Nebraska Calf Diarrhoea Virus
Host Goat
Clonality Polyclonal
Immunogen Purified Bovine Rotavirus (Nebraska Calf Diarrhoea Virus).
Specificity Recognizes ICPs & late structural (virion) antigens.
Cross reactivity is > 90% with Human Rotaviruses (reported).
Uninfected cell reactivity is negative against HEp-2 cells and WI-38 cells by Indirect Immunofluorescence.
Formulation 0.01M PBS, pH 7.2
State: Purified
State: Liquid purified Ig fraction (>95% pure)
Stabilizer: None
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Sodium Sulfate Precipitation and Ion Exchange Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Background Rotaviruses, members of the family Reoviridae, are a major cause of diarrhoea in young mammals. Rotavirus infections also result in economic losses in agriculture due to diarrhoea in calf, pig, sheep, and poultry rearing. Nebraska Calf Diarrhea Virus (NCVD) can affect calves up to 30 days of age or older. Diarrhoea begins 2 to 3 days after exposure. Diagnosis is by history, lesions (ulcers on the tongue, lips, and mouth) and diagnostic laboratory tests. Mortality rates may be as high as 50 percent, depending on the secondary bacteria present.
Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Rotaviruses are 70 nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection; therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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