VC1456 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, IP
Recommend Dilution	ELISA. Immunoprecipitation. Has been described to work in Immunohistochemistry on Frozen Sections and Immunofluorescence.
Reactivity	Bacteria
Host	Rabbit
Clonality	Polyclonal
Immunogen	Purified choleragenoid
Specificity	Reacts with the beta subunit of Cholera Toxin.
Formulation	PBS, pH 7.2 containing 0.09% Sodium Azide as preservative. State: Ig Fraction State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P01556
Background	The beta subunit of cholera toxin binds to a GM1-anglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit (and cholera toxin) activate the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
Synonyms	Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB, VC_1456
Reference Data

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