alpha 2 Macroglobulin (A2M) Mouse Monoclonal Antibody [Clone ID: 2N1/10]

Specifications

Product Data
Clone Name	2N1/10
Applications	ELISA, R
Recommend Dilution	ELISA. Radioimmunoassays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified alpha-2 macroglobulin from human plasma.
Specificity	This antibody recognises alpha 2-macroglobulin, a tetrameric glycoprotein of 720 kDa which functions as a proteinase inhibitor.
Formulation	PBS containing 0.09% Sodium azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	DEAE-chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	alpha-2-macroglobulin
Database Link	Entrez Gene 2 Human UniProt ID P01023
Background	Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.
Synonyms	Alpha-2-M, CPAMD5, Alpha 2 macroglobulin
Reference Data

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