LRP1 Mouse Monoclonal Antibody [Clone ID: 8G1]

Specifications

Product Data
Clone Name	8G1
Applications	FC, IF, IHC, WB
Recommend Dilution	Immunofluorescence. Immunohistochemistry: 1:20. Flow cytometry. Immunoblotting.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human LRP/α2MR.
Specificity	8G1 specifically reacts with the 515 kDa α-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocytederived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
Formulation	PBS buffer, pH 7.4 containing 0.5% BSA State: Purified State: Lyophilized purified IgG
Reconstitution Method	Restore in 1 ml dist. water
Purification	Protein A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	LDL receptor related protein 1
Database Link	Entrez Gene 4035 Human UniProt ID Q07954
Background	Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.
Synonyms	A2MR, APR, APOER
Reference Data

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