delta 2 Catenin (CTNND2) Mouse Monoclonal Antibody [Clone ID: J19]

Specifications

Product Data
Clone Name	J19
Applications	IHC, WB
Recommend Dilution	Immunoblotting. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: Ready-to-use (only after microwave treatment). Positive Control: Murine Brain, Retina.
Reactivity	Bovine, Human, Mouse, Rat, Zebrafish
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH
Specificity	This Monoclonal antibody reacts specifically with Neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Deltacatenin also binds to Presenilin-1, mutations of this protein are described to play a role in familial Alzheimer’s disease. No cross-reaction with other members of the Armadillo / Plakoglobin protein family. The antibody is positive with a 300 kD polypetide in Endothelia from blood vessels.
Formulation	State: Supernatant State: Liquid Culture Supernatant with 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	catenin delta 2
Database Link	Entrez Gene 1501 Human UniProt ID Q9UQB3
Background	Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta-Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimer's disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co-localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development.
Synonyms	CTNND2, NPRAP, Delta-catenin, Neurojungin, GT24
Reference Data

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