Adgre1 Rat Monoclonal Antibody [Clone ID: BM8]

Specifications

Product Data
Clone Name	BM8
Applications	FC, IF
Recommend Dilution	Has been described to work in FACS. Suggested Positive Control: Mouse monocytes.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Cultured macrophages
Specificity	This antibody recognizes the F4/80 antigen on major subpopulations of resident tissue macrophages (Schaller et al. 2002).  Antigen Distribution Isolated Cells: The antigen is expressed in vitro on over 80% of M-CSF stimulated bone marrow derived macrophages, after a few days of culture. It is absent from granulocytes, lymphocytes and thrombocytes. Tissue Sections: The antigen is detected on tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin) except lung. It is also present on Langerhans cells in the skin and Kupffer cells in the liver. In complete Freund's adjuvant induced granulomas, the antigen is expressed by inflammatory macrophages, but is absent from epitheloid cells.
Formulation	PBS, pH 7.2 Label: FITC State: Liquid purified Ig fraction Stabilizer: 10 mg/ml BSA Preservative: 0.09% Sodium Azide
Concentration	0.1 mg/ml
Purification	Affinity Chromatography
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	adhesion G protein-coupled receptor E1
Database Link	Entrez Gene 13733 Mouse UniProt ID Q61549
Background	The antigen expression increases upon maturation of macrophage precursors in bone marrow and blood as well as in ontogeny. BM8 is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas and has been shown to be a unique histological marker of the progression from peri-insulitis to β-cell destruction and diabetes in a mouse diabetes model.
Synonyms	Emr1, Gpf480
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.