Cytokeratin 18 (KRT18) Mouse Monoclonal Antibody [Clone ID: Ks18.04]
CAT#: BM2275P
Cytokeratin 18 (KRT18) mouse monoclonal antibody, clone Ks18.04, Purified
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CNY 4,851.00
货期*
5周
规格
Cited in 11 publications. |
Product images
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Specifications
Product Data | |
Clone Name | Ks18.04 |
Applications | IHC, WB |
Recommend Dilution | Western blot. Immunohistochemistry on Frozen and Paraffin Sections: 1/20 with PBS. Microwave treatment is recommended. Incubation time: 1h at 37°C, extended with paraffin sections (overnight at 2-8°C). |
Reactivity | Bovine, Canine, Hamster, Human, Mouse, Porcine, Rat, Sheep, Trout, Zebrafish |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human keratin K18 from HeLa cytoskeletal preparation |
Specificity | Ks 18.04 represents an excellent marker to discriminate simple epithelia from those of different origin. Tumors specifically detected: all adenocarcinoma; mammary carcinoma, urinary bladder carcinoma, undifferentiated carcinoma, cervix carcinoma, hepatocellular carcinoma. Polypeptide reacting: Mr 45 000 polypeptide (human keratin K18) of all simple type epithelia and basal cells of many squamous, nonepidermal epithelia. Tested Reactivities on Cultured Cell Lines: HeLa and MCF-7. |
Formulation | PBS, pH 7.4 State: Purified State: Lyophilized purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.09% Sodium azide |
Reconstitution Method | Restore in 1.0 ml distilled water. |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Gene Name | keratin 18 |
Database Link | |
Background | Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18. |
Synonyms | Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18 |
Reference Data |
Citations (11)
The use of this Antibodies has been cited in the following citations: |
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Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver
,Sharma AD, Cantz T, Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Arseniev L, Ott M,
Am. J. Pathol.
,PubMed ID 16049339
[KRT18]
|
Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies
,Zatloukal B, Kufferath I, Thueringer A, Landegren U, Zatloukal K, Haybaeck J,
PLoS ONE
,PubMed ID 24798445
[KRT18]
|
Mallory body--a disease-associated type of sequestosome
,Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H,
Hepatology
,PubMed ID 11981755
[KRT18]
|
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
,Ikenouchi J, Matsuda M, Furuse M, Tsukita S,
J. Cell. Sci.
,PubMed ID 12668723
[KRT18]
|
Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter
,Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A,
Development
,PubMed ID 22833126
[KRT18]
|
Detection of elevated caspase activation and early apoptosis in liver diseases
,Bantel H, Ruck P, Gregor M, Schulze-Osthoff K,
Eur. J. Cell Biol.
,PubMed ID 11322387
[KRT18]
|
cDNA sequences of the authentic keratins 8 and 18 in zebrafish
,Schaffeld M, Knappe M, Hunzinger C, Markl J,
Differentiation
,PubMed ID 12558605
[KRT18]
|
Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
,Gomi H, Yokoyama T, Fujimoto K, Ikeda T, Katoh A, Itoh T, Itohara S,
Neuron
,PubMed ID 7826639
[KRT18]
|
A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology
,BC!rtek J, VojtDsek B, StaskovC! Z, BC!rtkovC! J, KerekC)s Z, Rejthar A, KovarC-k J,
J. Pathol.
,PubMed ID 1716305
[KRT18]
|
Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule
,LauerovC! L, Kovarik J, BC!rtek J, Rejthar A, VojtDsek B,
Hybridoma
,PubMed ID 2461901
[KRT18]
|
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
,Moll R, Franke WW, Schiller DL, Geiger B, Krepler R,
Cell
,PubMed ID 6186379
[KRT18]
|
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