IGF1 Receptor (IGF1R) (alpha chain) Mouse Monoclonal Antibody [Clone ID: 1H7]
CAT#: BM2226P
IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Purified
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CNY 6,116.00
货期*
4周
规格
Cited in 4 publications. |
Specifications
Product Data | |
Clone Name | 1H7 |
Applications | FC, IHC, WB |
Recommend Dilution | Western Blot. Immunohistochemistry on Paraffin Sections: 1/10-1/40. Requires Protein digestion pre-treatment of paraffin sections (e.g. trypsin or pronase). Flow Cytometry: Use 10 µl of 1/10 diluted antibody to label 106 cells in 100 µl. Recommended Positive Control: Pancreas, placenta. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Purified Human placental IGF-I receptor. |
Specificity | This antibody recognizes CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane betasubunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221. We recommend the use of BM2226LE for this purpose. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction from tissue culture supernatant Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | insulin like growth factor 1 receptor |
Database Link | |
Background | There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor (also known as CD221) prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. |
Synonyms | IGF-I receptor, IGF1 Receptor |
Reference Data |
Citations (4)
The use of this Antibodies has been cited in the following citations: |
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IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma
,Beuschlein F, Jakoby J, Mentz S, Zambetti G, Jung S, Reincke M, S|ss R, Hantel C,
Mol. Cell. Endocrinol.
,PubMed ID 26994514
[IGF1R]
|
Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo — challenges and prospects
,null,
Oncotarget
,PubMed ID 26497207
[IGF1R]
|
Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency
,Hantel C, Lewrick F, Schneider S, Zwermann O, Perren A, Reincke M, S|ss R, Beuschlein F,
J. Clin. Endocrinol. Metab.
,PubMed ID 19952224
[IGF1R]
|
Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma
,Hantel C, Lewrick F, Reincke M, SC |
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