IGF1 Receptor (IGF1R) (alpha chain) Mouse Monoclonal Antibody [Clone ID: 1H7]

CAT#: BM2226LE

IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Low Endotoxin



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CNY 9,788.00


货期*
4周

规格
    • 500 ug

Cited in 2 publications.

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Specifications

Product Data
Clone Name 1H7
Applications FC, FN, IHC, WB
Recommend Dilution Functional Assays.
Western blotting.
Flow Cytometry:
Use 10 µl of 1/10 diluted antibody to label 106 cells in 100 µl.
Immunohistochemistry on Paraffin Sections: 1/10-1/40. This product requires protein digestion pre-treatment of paraffin sections e.g trypsin or pronase. Use pancreas or placenta as histology positive control tissue.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified Human placental IGF-I receptor.
Specificity Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting (Ref.1).
Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (Ref.1)
Formulation PBS without preservatives or stabilizers
State: Low Endotoxin
State: Liquid (sterile filtered) purified IgG fraction from tissue culture supernatant
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Condition Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name insulin like growth factor 1 receptor
Background CD221, a 155 kD tyrosine kinase, is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.
The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins.
Synonyms IGF-I receptor, IGF1 Receptor
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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