EGFL7 (C-term) Rabbit Polyclonal Antibody

CAT#: AP60008PU-N

EGFL7 (C-term) rabbit polyclonal antibody, Purified



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CNY 3,450.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IF, IHC, IP, WB
Recommend Dilution Western blot: 2-5 µg/ml.
Immunohistochemistry on Frozen sections.
Immnunocytochemistry: 10 µg/ml.
Immunoprecipitation: 1 µg/ml.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure (>95%) recombinant Human EGFL7 (Pro187-Ser273) C-terminus derived from E. coli.
Specificity This antibody recognizes Human VE-Statin / EGFL7 at C-term. Other species not tested.
Formulation PBS
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore in sterile water/PBS to a concentration of 0.1-1.0 mg/ml.
Purification Protein A chromatography
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name EGF like domain multiple 7
Background EGFL7 (epidermal growth factor-like domain 7) is a secreted angiogenic factor that is highly conserved in vertebrates. Most secreted angiogenic signaling molecules, including VEGF and FGF-2, are mainly expressed by non-endothelial cell types such as fibroblasts. In contrast, EGFL7 is unique because it is almost exclusively expressed by and acts on endothelial cells. EGFL7 expression is highest when the endothelium is in an active, proliferating state. This factor acts as a chemo-attractant for endothelial cells and binds to components of the extracellular matrix. In vivo, EGFL7 is important for regulating tubulogenesis in Zebrafish and for controlling vascular patterning and integrity in mice. Its function in blood vessel development is mediated, at least in part, through modulation of Notch signaling. There is evidence that support a role for EGFL7 in developmental and postnatal angiogenesis as well as a potential role for EGFL7 in vascular repair.
EGFL7, also known as VE-Statin (Vascular endothelial Statin), is a endothelial-specific protein that is a marker for progenitor, embryonic and adult endothelial cells. Mature soluble EGFL7/VE-Statin is a 41 kDa protein containing an N-terminal cysteine rich EMI domain, followed by two EGF-like domains and a coiled-coil region. EGFL7/VE-Statin inhibits PDGF-BB-induced smooth muscle cell migration. The amino acid sequence of human EGFL7/VE-Statin is 80% identical to that of mouse EGFL7/VE-Statin.
Synonyms EGF-like protein 7, EGF like protein 7, VE-statin, NOTCH4-like protein, Zneu1, MEGF7, UNQ187, PRO1449
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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