IKK alpha (CHUK) pSer176/177 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:500~1:1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around phosphorylation site of serine 176/177 (Q-G-S(p)-L-C) derived from Human IKK-alpha/beta (KLH-conjugated)
Specificity	The antibody detects endogenous level of IKK- alpha/beta only when phosphorylated at serine 176/177.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	85 kDa
Gene Name	conserved helix-loop-helix ubiquitous kinase
Database Link	Entrez Gene 1147 Human UniProt ID O15111
Background	Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3.
Synonyms	CHUK, TCF16, I kappa-B kinase alpha, I kappa-B kinase beta, IkBKA, IkBKB, IKK-alpha, IKK-beta, IKK-A, IkappaB kinase, I-kappa-B kinase 1, NFKBIKA, IKK1, IKK2
Reference Data

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