EIF4EBP1 pThr70 Rabbit Polyclonal Antibody
CAT#: AP55799PU-N
EIF4EBP1 pThr70 rabbit polyclonal antibody, Aff - Purified
Size: 50 ul
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CNY 2,250.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on paraffin sections: 1:50~1:100 . |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1 (KLH-conjugated) |
Specificity | The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70. |
Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity chromatography using epitope-specific peptide |
Conjugation | Unconjugated |
Storage Condition | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Predicted Protein Size | 12 kDa |
Gene Name | eukaryotic translation initiation factor 4E binding protein 1 |
Database Link | |
Background | 4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
Synonyms | PHAS-I, PHAS-1, PHAS1 |
Reference Data |
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