Slc17a7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, EM, IHC, WB
Recommend Dilution	ELISA. RIA: 1/500 Western Blot: 1/500. Electron Microscopy: 1/200. Immunohistochemistry.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 17 residue synthetic peptide derived from C-terminal domain of Rat VGLUT1.
Specificity	This antibody reacts with Rat 55-60 kDa VGLUT1 protein of BON cells stably expressing VGLUT1 and of total Rat brain extracts. No cross reactivity was detected with VGLUT2 and VGLUT3.
Formulation	0.1M Tris, 0.1 M Glycine, 2% Sucrose State: Aff - Purified State: Lyophilized purified IgG fraction Preservative: None
Reconstitution Method	Restore in distilled water.
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 17 member 7
Database Link	Entrez Gene 116638 Rat UniProt ID Q62634
Background	VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate.
Synonyms	Vesicular glutamate transporter 1, BNPI
Reference Data

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