c Maf (MAF) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, EMSA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000. Immunohistochemistry: 1/50-1/500. Useful for Electrophoretic Mobility Shift Assay (EMSA).
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Maf-GST fusion protein
Specificity	This antibody reacts with 47 kDa Maf protein derived from a transfected CEF cell line.
Formulation	State: Serum State: Lyophilized serum
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	MAF bZIP transcription factor
Database Link	Entrez Gene 4094 Human UniProt ID O75444
Background	c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
Synonyms	Transcription factor Maf, Proto-oncogene c-maf, V-maf
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.