Xanthine Oxidase (XDH) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:1;000. Western blot: 1:100~500. Immunohistochemistry on paraffin sections: 1:50~100.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 213~242 amino acids from the N-terminal region of human XDH
Specificity	This antibody detects Xanthine dehydrogenase/oxidase (N-term).
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	xanthine dehydrogenase
Database Link	Entrez Gene 22436 MouseEntrez Gene 7498 Human UniProt ID P47989
Background	XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Synonyms	Xanthine dehydrogenase/oxidase
Note	Molecular Weight: 146424 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

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