NUDT15 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Flow cytometry: 1/10-1/50. Immunohistochemistry on Paraffin sections: 1/50-1/100. Western blot: 1/1000. Enzyme immunoassay: 1/1000.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 89-118aa) of human NUDT15.
Specificity	This antibody recognizes NUDT15.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	nudix hydrolase 15
Database Link	Entrez Gene 55270 Human UniProt ID Q9NV35
Background	Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
Synonyms	MTH2, MutT homolog 2, Nudix motif 15
Note	Molecular Weight: 18609 Da
Reference Data

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