GPCR MRGX2 (MRGPRX2) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot:  1/100-1/500. Enzyme immunoassay:  1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 286-316aa) of human MRGPRX2.
Specificity	This antibody recognizes MRGPRX2 at C-term.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	MAS related GPR family member X2
Database Link	Entrez Gene 117194 Human UniProt ID Q96LB1
Background	MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Synonyms	MRGX2
Note	Molecular Weight: 37099 Da
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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