Mannose Receptor (MRC1) (N-term) Rabbit Polyclonal Antibody
CAT#: AP52743PU-N
Mannose Receptor (MRC1) (N-term) rabbit polyclonal antibody, Aff - Purified
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CNY 6,314.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1/100-1/500. Enzyme immunoassay: 1/1000. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 358-388aa) of human CD206 / MRC1. |
Specificity | This antibody recognizes CD 206 / MRC1 at N-term. |
Formulation | PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Purified through a Protein A column followed by peptide affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | mannose receptor, C type 1 |
Database Link | |
Background | CD206 is a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells. |
Synonyms | Macrophage mannose receptor, CLEC13D, CLEC13DL, MRC1L1 |
Note | Molecular Weight: 166046 Da |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
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