GUCY2D (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Western Blot: 1/1000.  Flow Cytometry: 1/10-1/50.  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D / RETGC1
Specificity	This antibody recognizes Human GUCY2D / RETGC1 (Center).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	guanylate cyclase 2D, retinal
Database Link	Entrez Gene 3000 Human UniProt ID Q02846
Background	This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].
Synonyms	Retinal guanylyl cyclase 1, RETGC-1, retinal Guanylate cyclase 2D, CORD6, GUC1A4, GUC2D, RETGC, PGCD
Note	Molecular Weight: 120059 Da
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Olfactory transduction, Purine metabolism

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