EIF4EBP1 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/50 - 1/100. Immunohistochemistry on paraffin sections: 1/10 - 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Immunized with a KLH conjugated synthetic peptide between 31-61 amino acids from the Central region of human EIF4EBP1
Specificity	This antibody reacts to EIF4EBP1.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	12580 Da
Gene Name	eukaryotic translation initiation factor 4E binding protein 1
Database Link	Entrez Gene 1978 Human UniProt ID Q13541
Background	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].
Synonyms	PHAS-I, PHAS-1, PHAS1
Reference Data
Protein Pathways	Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway

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