AKR1C3 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	ELISA: 1/1000. Western blotting: 1/1000. Flow Cytometry: 1/10 - 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human AKR1C3
Specificity	This antibody reacts to AKR1C3.
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	aldo-keto reductase family 1, member C3
Database Link	Entrez Gene 8644 Human UniProt ID P42330
Background	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms	HSD17B5, KIAA0119, PGFS, Dihydrodiol dehydrogenase 3, 3-alpha-HSD type II, 17-beta-hydroxysteroid dehydrogenase type 5
Note	Molecular Weight: 36853 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450

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