S adenosylhomocysteine hydrolase (AHCY) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/50 - 1/100. Flow Cytometry: 1/10 - 1/50.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 86-118 amino acids from the N-terminal region of human AHCY
Specificity	This antibody reacts to AdoHcyase.
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	adenosylhomocysteinase
Database Link	Entrez Gene 269378 MouseEntrez Gene 191 Human UniProt ID P23526
Background	S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	Adenosylhomocysteinase, SAHH
Note	Molecular Weight: 47716 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cysteine and methionine metabolism, Metabolic pathways, Selenoamino acid metabolism

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