PSMC3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blotting (1 - 3 µg/ml) Immunohistochemsitry on paraffin embedded sections (4 - 8 µg/ml)
Reactivity	Bovine, Canine, Chicken, Human, Mouse, Rat, Zebrafish, African clawed frog
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-PSMC3 antibody: synthetic peptide directed towards the middle region of human PSMC3.
Formulation	State: Aff - Purified State: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purification	Purified using Protein A affinity column.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Gene Name	proteasome 26S subunit, ATPase 3
Database Link	Entrez Gene 19182 MouseEntrez Gene 29677 RatEntrez Gene 5702 Human UniProt ID P17980
Background	PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Synonyms	26S protease regulatory subunit 6A, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, Tat-binding protein 1, TBP-1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Proteasome

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