GDNF Receptor alpha 2 (GFRA2) Chicken Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	ELISA: 1/128000-1/160000. Western blot: 1/5000-1/10000. Immunofluorescence: 1/500-1/1000.
Reactivity	Human
Host	Chicken
Clonality	Polyclonal
Immunogen	Recombinant His-tagged human GFRa-2 protein produced using CHO-based. For production of hGFRa-2, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affinity chromatography following gel-filtration from cell culture supernatant.
Specificity	This antibody detects Human GFRa-2 and doesn’t cross-react with hGFRa-1, hGFRa-3, hGFRa-4. Other species not tested.
Formulation	Concentrated Ammonium Sulphate in PBS pH 7.4 State: Aff - Purified State: Liquid purified IgY fraction
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store at 2-8°C. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.
Gene Name	GDNF family receptor alpha 2
Database Link	Entrez Gene 2675 Human UniProt ID O00451
Background	Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The GFRa-1 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor (www.ncbi.nlm.nih.gov/gene/2674).
Synonyms	GFR-alpha-2, Neurturin receptor alpha, GDNF receptor beta, RET ligand 2, GDNFRB, RETL2, TRNR2
Reference Data

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