UBR4 (C-term) Goat Polyclonal Antibody
CAT#: AP33295PU-N
UBR4 (C-term) goat polyclonal antibody, Aff - Purified
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CNY 5,371.00
货期*
4周
规格
Specifications
Product Data | |
Applications | ELISA, IHC |
Recommend Dilution | Peptide ELISA: 1/128000 (Detection Limit). Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. In paraffin embedded Spleen shows various types of subnuclear staining in select splenocytes and additional membrane plus cytoplasm staining elsewhere. |
Reactivity | Bovine, Canine, Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide with sequence from the C Terminus of the protein sequence according to NP_065816.2. |
Specificity | This antibody recognizes UBR4 / ZUBR1. |
Formulation | Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | ubiquitin protein ligase E3 component n-recognin 4 |
Database Link | |
Background | p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions. |
Synonyms | KIAA0462, KIAA1307, RBAF600, ZUBR1 |
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