gamma Catenin (JUP) (N-term, 5-21) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunoblotting (Western blot): 1/2000. Immunohistochemistry on Frozen Sections: 1/100. Immunohistochemistry on Paraffin Sections: 1/50 (after microwave treatment). Cytological Material. Incubation Time: 1 h at RT extended with paraffin sections.
Reactivity	Human, Mouse
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic N-terminus of Human Plakoglobin (aa 5-21), identical to gamma-Catenin
Specificity	Specific detection of Mr 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (also described as Gamma-Catenin). Excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis). Especially useful for studying plakoglobin mutations in cardiomyopathies (e.g. ARVC, see References below).
Formulation	State: Serum State: Liquid prediluted stabilized antiserum with 0.09% Sodium Azide and 0.5% BSA
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	junction plakoglobin
Database Link	Entrez Gene 3728 Human UniProt ID P14923
Background	Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
Synonyms	Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3
Reference Data

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