Alpha Fodrin (SPTAN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western Blot: 1/3000.  Immunohistochemistry. Immunofluorescence: 1/500.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant construct containing the seventh, eighth and ninth repeats of Human Alpha II Spectrin expressed in and purified from E. Coli.
Specificity	Specific for Alpha II Spectrin.
Formulation	State: Serum State: Affinity purified antibody containing 10 mM sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	spectrin alpha, non-erythrocytic 1
Database Link	Entrez Gene 6709 Human UniProt ID Q13813
Background	The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).
Synonyms	Spectrin non-erythroid alpha chain, Alpha-II spectrin, Fodrin alpha chain, SPTA2
Reference Data

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