TAPA1 (CD81) Rat Monoclonal Antibody [Clone ID: QV-6A8-S3]
CAT#: AP32979PU-N
TAPA1 (CD81) rat monoclonal antibody, clone QV-6A8-S3, Purified
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CNY 5,660.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | QV-6A8-S3 |
Applications | ELISA, FC, WB |
Recommend Dilution | Flow Cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. |
Reactivity | Human |
Host | Rat |
Clonality | Monoclonal |
Immunogen | cDNA encoding Human CD81 |
Specificity | Recognizes Human CD81. Other species not tested. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells. |
Formulation | PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | CD81 molecule |
Database Link | |
Background | CD81 (TAPA-1) belongs to the transmembrane 4 superfamily (tetraspanin family). CD81 is a widely expressed cell-surface protein that is characterized by the presence of four transmembranic domains, short N and C termini, a small extracellular loop (SEL) and a large extra-cellular loop (LEL) (1). It is expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin and plays a role in the regulation of cell development, cell-growth and signal transduction. CD81 plays a critical role in Hepatitis C Infection and is involved in HCV entry due to its ability to interact with virus' E1/E2 glycoproteins (2,3). CD81 is an essential HCV host factor as silencing of CD81 expression by CD81-specific monoclonal antibodies in hepatoma cells inhibits HCV entry (4). |
Synonyms | S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission
,Fofana I, Xiao F, Thumann C, Turek M, Zona L, Tawar RG, Grunert F, Thompson J, Zeisel MB, Baumert TF,
PLoS ONE
,PubMed ID 23704981
[CD81]
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