GPR48 (LGR4) Rat Monoclonal Antibody [Clone ID: BBX-1H1]

Specifications

Product Data
Clone Name	BBX-1H1
Applications	ELISA, FC, WB
Recommend Dilution	Flow Cytometry: 1.2 µg/106 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	cDNA encoding Human LGR4
Specificity	Recognizes Human LGR4 / GPR48. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	leucine-rich repeat containing G protein-coupled receptor 4
Database Link	Entrez Gene 55366 Human UniProt ID Q9BXB1
Background	LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains (1,3). LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart (2). LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.
Synonyms	G-protein coupled receptor 48
Reference Data

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